Progressive loss of the ascending dopaminergic projection in the basal ganglia is a
fundamental pathological feature of Parkinson's disease. Studies in animals and humans …

The vast majority of centers use electrophysiological mapping techniques to finalize target
selection during the implantation of deep brain stimulation (DBS) leads for the treatment of …

Background Increased neuronal activity in the subthalamic nucleus and the pars interna of
the globus pallidus is thought to account for motor dysfunction in patients with Parkinson's …

Objective Our aim was to compare in a prospective blinded study the cognitive and mood
effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation …

Single-cell recording of the subthalamic nucleus (STN) was undertaken in 14 patients with
Parkinson's disease submitted to surgery. Three hundred and fifty neurones were recorded …

There is little debate that deep brain stimulation (DBS) has been an effective tool in the
treatment of Parkinson's disease as well as other movement disorders. There remains …

Microelectrode recording was performed in the basal ganglia of 3 patients with generalized
dystonia and 1 patient with hemiballismus secondary to a brainstem hemorrhage. Neuronal …

Deep brain stimulation (DBS) is a widely accepted therapy for medically refractory
Parkinson's disease (PD). Both globus pallidus internus (GPi) and subthalamic nucleus …

This reference presents a new collection of diagrams of the human thalamus, basal ganglia,
and adjoining structures for accurate targeting in stereotactic functional neurosurgery. This …

Chronic electrical stimulation of the brain, known as deep brain stimulation (DBS), has
become a preferred surgical treatment for medication-refractory movement disorders …