Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …

Histone modifications not only play important roles in regulating chromatin structure and
nuclear processes but also can be passed to daughter cells as epigenetic marks …

While global chromatin conformation studies are emerging, very little is known about the
chromatin conformation of human telomeres. Most studies have focused on the role of …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

The origin recognition complex (ORC) binds sites from which DNA replication is initiated. We
address ORC binding selectivity in vivo by mapping∼ 52,000 ORC2 binding sites …

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …

DNA replication in eukaryotic cells initiates from multiple replication origins that are
distributed throughout the genome. Coordinating the usage of these origins is crucial to …

The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …