Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex
etiology. Apoptosis, a biological process that plays an essential role in normal physiology to …

Alzheimer's disease (AD), the most common neurodegenerative disorder, is the leading
cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology …

Abstract Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy
compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is …

Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

Oxidative stress is associated with the progression of Alzheimer's disease (AD). Reactive
oxygen species can modify lipids, DNA, RNA, and proteins in the brain. The products of their …

Abstract Trisomy 21 (T21) causes Down syndrome and an early-onset form of Alzheimer's
disease (AD). Here, we used human induced pluripotent stem cells (hiPSCs) along with …

Integration of diagnostic and therapeutic functions in a single platform namely theranostics
has become a cornerstone for personalized medicine. Theranostics platform facilitates …

Prion diseases typically have long pre-clinical incubation periods during which time the
infectious prion particle and infectivity steadily propagate in the brain. Abnormal neuritic …

Apoptosis, classically initiated by caspase pathway activation, plays a prominent role during
normal brain development as well as in neurodegeneration. The noncanonical, nonlethal …

Abnormal deposition of neuriticplaques is the uniqueneuropathological hallmark of
Alzheimer's disease (AD). Amyloid β protein (Aβ), the major component of plaques, is …