Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …

Identification of B‐cell epitopes is a fundamental step for development of epitope‐based
vaccines, therapeutic antibodies, and diagnostic tools. Epitope‐based antibodies are …

The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …

Antibodies are proteins that recognize the molecular surfaces of potentially noxious
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …

The interaction between antibodies and antigens is one of the most important immune
system mechanisms for clearing infectious organisms from the host. Antibodies bind to …

The binding of antigens to antibodies is one of the key events in an immune response
against foreign molecules and is a critical element of several biomedical applications …

Motivation: Antibodies are currently the most important class of biopharmaceuticals.
Development of such antibody-based drugs depends on costly and time-consuming …

The majority of biological processes are mediated via protein–protein interactions.
Determination of residues participating in such interactions improves our understanding of …

Antibodies are vital proteins of the immune system that recognize potentially harmful
molecules and initiate their removal. Mammals can efficiently create vast numbers of …

Abstract In vertebrates, immunoglobulins (Igs), commonly known as antibodies, play an
integral role in the armamentarium of immune defense against various pathogens. After an …