IgG4 is the least abundant subclass of IgG in human serum and has unique functional
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …

Background and Objectives Describe the unique functions of immunoglobulin G4 (IgG4) in
IgG4-neurologic disorders (IgG4-ND) and explain why, in contrast to their IgG1-counterparts …

Autoimmune diseases of the peripheral nervous system have so far been treated mainly with
exogenous high-dose intravenous immunoglobulins (IVIg), that act through several …

Autoimmune neuropathy associated with antibodies against pan-neurofascin is a new
subtype of nodo-paranodopathy. It is relevant because it is associated with high morbidity …

BLyS and APRIL have the capability to bind to B cells within the body, allowing these cells to
evade elimination when they should naturally be removed. While BLyS primarily plays a role …

AN have emerged as a new diagnostic category pathologically different from acquired
demyelinating neuropathies. Clinically they overlap with GBS and CIDP although they …

Organ-specific autoimmunity is often characterized by autoantibodies targeting proteins
expressed in the affected tissue. A subgroup of autoimmunopathies has recently emerged …

The main IgG4 antibody–mediated neurological disorders (IgG4-ND) include MuSK
myasthenia; CIDP with nodal/paranodal antibodies to Neurofascin-155, contactin-1/caspr-1 …

Abstract Purpose of Review Recognition of node of Ranvier as the site of injury in
inflammatory neuropathies contributed to discovery of antibodies against the …

Background and Objectives IgG4 autoantibodies to neurofascin-155 (Nfasc155) are
associated with a subgroup of patients with chronic inflammatory demyelinating …