The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women
after menopause and may lead to heart failure. While evidence suggests that estrogens …

Hypertension is the most prevalent cardiovascular disease of the adult population and is
closely associated with serious cardiovascular events. The burden of hypertension with …

The role of the endogenous apelin system in pregnancy is not well understood. Apelin's
actions in pregnancy are further complicated by the expression of multiple forms of the …

Preeclampsia is a syndrome with diverse clinical presentation that currently has no cure.
The apelin receptor system is a pleiotropic pathway with a potential for therapeutic targeting …

Background: Male-female differences in the expression of hypertension and in end-organ
damage are evident in both experimental models and human subjects, with males exhibiting …

Initial studies found that female Dahl salt-sensitive (DS) rats exhibit greater blood pressure
(BP) salt sensitivity than female spontaneously hypertensive rats (SHR). On the basis of the …

Background Menopause is associated with higher risks of chronic kidney disease. We
determined the effect of nitrate on ovariectomy-induced kidney dysfunction Methods Control …

This study determined the contribution of chronic salt loading and early loss of ovarian
hormones on diastolic function in the hypertensive female mRen (2). Lewis rat, a …

Background: We investigated renal effects of nebivolol, a selective β 1-receptor blocker with
additional antioxidative ability, in spontaneously hypertensive rats (SHR) where increased …

New therapeutic strategies for chronic kidney disease (CKD) are necessary to offset the
rising incidence of CKD and donor shortage. Erythropoietin (EPO), a cytokine produced by …