The coordinated movement of organic anions (eg, drugs, metabolites, signaling molecules,
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …

The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

Quantitative prediction of drug‐drug interactions (DDIs) involving organic anion transporting
polypeptide (OATP) 1B1/1B3 inhibition is limited by uncertainty in the translatability of …

Current challenges with the in vitro–in vivo extrapolation (IVIVE) of hepatic uptake clearance
involving organic anion–transporting polypeptide (OATP) 1B1/1B3 hinder drug design …

ABSTRACT Introduction: Janus kinase inhibitors (JAKinibs) constitute an emerging and
promising pharmacological class of anti-inflammatory or anti-cancer drugs, used notably for …

Purpose The involvement of the intestinally expressed xenobiotic transporters P-
glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) have been implicated in …

Introduction Membrane transporters are now widely recognized for their role in the
absorption, distribution, clearance, and elimination of drugs. The organic cation transporters …

The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing
enzymes and transporters. Non-alcoholic steatohepatitis (NASH) causes disease-specific …

Prospective predictions of human hepatic clearance for anionic/zwitterionic compounds,
which are oftentimes subjected to transporter-mediated uptake, are challenging in drug …

Abstract 3D spheroids of primary human hepatocytes (3D PHH) retain a differentiated
phenotype with largely conserved metabolic function and proteomic fingerprint over weeks …