The generation of a functional T cell repertoire in the thymus is mainly orchestrated by
thymic epithelial cells (TECs), which provide developing T cells with cues for their …

Abstract Development of immunocompetent T cells in the thymus is required for effective
defence against all types of pathogens, including viruses, bacteria and fungi. To this end, T …

The thymus' key function in the immune system is to provide the necessary environment for
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …

The thymus is a highly specialized organ that plays an indispensable role in the
establishment of self-tolerance, a process characterized by the “education” of developing T …

T cells develop from circulating precursor cells, which enter the thymus and migrate through
specialized subcompartments that support their maturation and selection. In humans, this …

Thymus development is critical to the adaptive immune system, yet a comprehensive
transcriptional framework capturing thymus organogenesis at single-cell resolution is still …

The thymus is a primary lymphoid organ, essential for T cell maturation and selection. There
has been long-standing interest in processes underpinning thymus generation and the …

Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by
mediating negative selection of autoreactive T cells through the collective expression of the …

To induce central T‐cell tolerance, medullary thymic epithelial cells (mTEC) collectively
express most protein‐coding genes, thereby presenting an extensive library of tissue …

Paraneoplastic neurological disorders are immune-mediated diseases understood to
manifest as part of a misdirected anti-tumor immune response. Paraneoplastic neurological …