Dynamic DNA methylation: In the right place at the right time
The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …
regulation depicts this covalent modification as a stable repressive regulator of promoter …
Active turnover of DNA methylation during cell fate decisions
DNA methylation is a key layer of epigenetic regulation. The deposition of methylation marks
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
Summary N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
[HTML][HTML] Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
A general approach for heritably altering gene expression has the potential to enable many
discovery and therapeutic efforts. Here, we present CRISPRoff—a programmable epigenetic …
discovery and therapeutic efforts. Here, we present CRISPRoff—a programmable epigenetic …
Editing DNA methylation in the mammalian genome
Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …
expression networks in many biological processes. However, investigation of the functions …
[HTML][HTML] Induction of expansion and folding in human cerebral organoids
An expansion of the cerebral neocortex is thought to be the foundation for the unique
intellectual abilities of humans. It has been suggested that an increase in the proliferative …
intellectual abilities of humans. It has been suggested that an increase in the proliferative …
Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis
A major challenge in understanding vertebrate embryogenesis is the lack of topographical
transcriptomic information that can help correlate microenvironmental cues within the …
transcriptomic information that can help correlate microenvironmental cues within the …
Using DNA methylation profiling to evaluate biological age and longevity interventions
The DNA methylation levels of certain CpG sites are thought to reflect the pace of human
aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG …
aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG …
Multiplexed profiling facilitates robust m6A quantification at site, gene and sample resolution
D Dierks, MA Garcia-Campos, A Uzonyi, M Safra… - Nature …, 2021 - nature.com
Abstract N 6-methyladenosine (m6A) is the most prevalent modification of messenger RNA
in mammals. To interrogate its functions and dynamics, there is a critical need to quantify …
in mammals. To interrogate its functions and dynamics, there is a critical need to quantify …
Transcriptional and epigenetic control of brown and beige adipose cell fate and function
White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …