Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …

The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this
pathway represent the main treatment modality. Endocrine therapy has proven successful in …

Although cancer was originally considered a disease driven only by genetic mutations, it has
now been proven that it is also an epigenetic disease driven by DNA hypermethylation …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

All major biological macromolecules (DNA, RNA, proteins and lipids) undergo enzyme-
catalysed covalent modifications that impact their structure, function and stability. A variety of …

BRCA1 mutations are associated with increased breast and ovarian cancer risk. BRCA1-
mutant tumors are high-grade, recurrent, and often become resistant to standard therapies …

Abstract Aims RN7SK (7SK), a highly conserved non-coding RNA, serves as a transcription
regulator via interaction with a few proteins. Despite increasing evidences which support the …

Cells have evolved a robust and highly regulated DNA damage response to preserve their
genomic integrity. Although increasing evidence highlights the relevance of RNA regulation …

The SARS-CoV-2 spike protein is a critical component of vaccines and a target for
neutralizing monoclonal antibodies (nAbs). Spike is also undergoing immunogenic selection …

ABSTRACT RNA methylation, catalysed by a set of RNA methyltransferases (RNMTs),
modulates RNA structures, properties, and biological functions. RNMTs are increasingly …