Opinion Statement The main purpose of the TNM system is to provide an anatomic-based
classification to adequately depict cancer prognosis. Accurate cancer staging is important for …

Opinion statement The epidemiology of head and neck squamous cell carcinoma (HNSCC)
has shifted dramatically over the last 50 years, as smoking-related HNSCCs decrease in …

Answer questions and earn CME/CNE The recently released eighth edition of the American
Joint Committee on Cancer (AJCC) Staging Manual, Head and Neck Section, introduces …

The TNM classification of malignant tumours is a mainstay tool in clinical practice and
research for prognostic assessment of patients, treatment allocation and trial enrolment, as …

Introduction The purpose of this study was to test whether the 8th edition of the AJCC/UICC
TNM staging system (UICC) precisely differentiates between stages and reflects disease …

Oncologists should be aware of three major modifications and additions to staging head and
neck cancer that became effective in 2018. Oral cavity cancers have the addition of depth of …

Human papillomavirus (HPV)-related oropharyngeal squamous cell cancer (OPSCC) has
emerged as a distinct clinical entity of head and neck cancer with expected high survival …

Tumor breaching the capsule of a lymph node is termed extranodal extension (ENE). It
reflects aggressiveness of a tumor, creates anatomic challenges for disease clearance, and …

The oropharynx has become the leading primary site for Human Papilloma Virus (HPV)-
associated head and neck cancer. HPV positive oropharyngeal squamous cell carcinoma …

Abstract Background The 8th edition American Joint Committee on Cancer staging system
for resected HPV-positive oropharynx carcinoma (HPV+ OPC) highlights high node number …