The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

Almost half of all enzymes must associate with a particular metal to function. An ambition is
to understand why each metal–protein partnership arose and how it is maintained. Metal …

Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

The metal-responsive transcription factor-1 (MTF-1, also termed MRE-binding transcription
factor-1 or metal regulatory transcription factor-1) is a pluripotent transcriptional regulator …

The biological effects of environmental metal contamination are important issues in an
industrialized, resource-dependent world. Different metals have different roles in biology …

Copper (Cu) is essential for development and proliferation, yet the cellular requirements for
Cu in these processes are not well defined. We report that Cu plays an unanticipated role in …

The widespread occurrence of cadmium in the environment continues to pose a threat to
human health despite attempts at limiting its technological uses. The biologically significant …

Heavy metals are both integral parts of cells and environmental toxicants, and their
deregulation is associated with severe cellular dysfunction and various diseases. Here we …

Highlights•Metal ions play multiple roles in osmoregulation and homeostasis.•Many metals
are cofactors of metalloenzymes.•Ion balance underpins environmental resilience, for …

Metal-regulatory transcription factor 1 (MTF1) is a conserved metal-binding transcription
factor in eukaryotes that binds to conserved DNA sequence motifs, termed metal response …