Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

The inorganic chemistry of the cobalt corrinoids, derivatives of vitamin B 12, is reviewed, with
particular emphasis on equilibrium constants for, and kinetics of, their axial ligand …

Vitamin B 12 is an essential biomolecule that assists in the catalysis of methyl transfer and
radical-based reactions in cellular metabolism. The structure of B 12 is characterized by a …

Fluorescent detection in cells has been tremendously developed over the years and now
benefits from a large array of reporters that can provide sensitive and specific detection in …

Metal homeostasis is central to all forms of life, as metals are essential micronutrients with
toxic effects at elevated levels. Macromolecular machines facilitate metal uptake into the …

RNA-targeting small-molecule therapeutics is an emerging field hindered by an incomplete
understanding of the basic principles governing RNA–ligand interactions. One way to …

The ability to sense and respond to intracellular metabolite levels enables cells to adapt to
environmental conditions. Many prokaryotes use riboswitches—structured RNA elements …

Antibiotic resistance remains a pressing global concern, with most antibiotics targeting the
bacterial ribosome or a limited range of proteins. One class of underexplored antibiotic …

The btuB riboswitch is a regulatory RNA sequence controlling gene expression of the outer
membrane B12 transport protein BtuB by specifically binding coenzyme B12 (AdoCbl) as its …

The natural vitamin B12‐derivatives are intriguing complexes of cobalt that entrap the metal
within the strikingly skewed and ring‐contracted corrin ligand. Here, we describe the …