Validation of protein structural models using THz spectroscopy: a promising approach to solve three-dimensional structures

M Mernea, O Calborean, O Grigore, T Dascalu… - Optical and Quantum …, 2014 - Springer
Terahertz (THz) spectroscopy is a promising technique for the study of protein structure and
internal flexibility. Here, we used THz spectroscopy and molecular modeling for bovine …

The flexibility of hydrated bovine serum albumin investigated by THz spectroscopy and molecular modeling

M Mernea, O Calborean, L Petrescu… - … on Optics: Micro-to …, 2010 - spiedigitallibrary.org
The native cellular environment represents a crowded system comprising high
concentrations of soluble molecules that interact mostly in a nonspecific manner. Some of …

Protein association investigated by THz spectroscopy and molecular modeling

M Mernea, O Calborean, L Petrescu… - … Applications in Life …, 2010 - spiedigitallibrary.org
Macromolecular crowding is a common intracellular phenomenon that causes
conformational changes of proteins and protein association. We investigated these …

Bovine serum albumin 3D structure determination by THz spectroscopy and molecular modeling

M Mernea, A Leca, T Dascalu, D Mihailescu - Terahertz and Mid Infrared …, 2011 - Springer
The low frequency collective movements of proteins associated with biologically relevant
conformational transitions are situated in the terahertz (THz) spectral region. THz …

THz spectroscopy and molecular modeling of bovine serum albumin under various hydration conditions

M Mernea, O Calborean, L Petrescu… - … , and Systems V, 2011 - spiedigitallibrary.org
Bovine serum albumin (BSA) is the most abundant protein in bovine plasma; its three
dimensional structure is yet unknown. We investigated the structure and dynamics of BSA in …

Proteins vibrations in THz frequency domain

M Mernea, O Calborean, L Petrescu… - 2010 2nd IEEE …, 2010 - ieeexplore.ieee.org
THz spectroscopy was used to investigate bovine serum albumin (BSA) flexibility in
conditions ranging from lyophilised BSA to dilute 10% w/w BSA solution and highly …

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