CRISPR/Cas9 landscape: Current state and future perspectives
M Tyumentseva, A Tyumentsev, V Akimkin - International Journal of …, 2023 - mdpi.com
CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 is a unique
genome editing tool that can be easily used in a wide range of applications, including …
genome editing tool that can be easily used in a wide range of applications, including …
AcrPred: A hybrid optimization with enumerated machine learning algorithm to predict Anti-CRISPR proteins
CRISPR-Cas, as a tool for gene editing, has received extensive attention in recent years.
Anti-CRISPR (Acr) proteins can inactivate the CRISPR-Cas defense system during …
Anti-CRISPR (Acr) proteins can inactivate the CRISPR-Cas defense system during …
In silico approaches for prediction of anti-CRISPR proteins
KS Makarova, YI Wolf, EV Koonin - Journal of molecular biology, 2023 - Elsevier
Numerous viruses infecting bacteria and archaea encode CRISPR-Cas system inhibitors,
known as anti-CRISPR proteins (Acr). The Acrs typically are highly specific for particular …
known as anti-CRISPR proteins (Acr). The Acrs typically are highly specific for particular …
CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing
F Zhou, X Yu, R Gan, K Ren, C Chen… - Nucleic acids …, 2023 - academic.oup.com
The CRISPR-Cas system is a highly adaptive and RNA-guided immune system found in
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
Widespread CRISPR-derived RNA regulatory elements in CRISPR-Cas systems
CRISPR-cas loci typically contain CRISPR arrays with unique spacers separating direct
repeats. Spacers along with portions of adjacent repeats are transcribed and processed into …
repeats. Spacers along with portions of adjacent repeats are transcribed and processed into …
oriTDB: a database of the origin-of-transfer regions of bacterial mobile genetic elements
G Liu, X Li, J Guan, C Tai, Y Weng… - Nucleic Acids …, 2025 - academic.oup.com
Conjugation and mobilization are two important pathways of horizontal transfer of bacterial
mobile genetic elements (MGEs). The origin-of-transfer (oriT) region is crucial for this …
mobile genetic elements (MGEs). The origin-of-transfer (oriT) region is crucial for this …
[HTML][HTML] Ecology and evolution of phages encoding anti-CRISPR proteins
CRISPR-Cas are prokaryotic defence systems that provide protection against invasion by
mobile genetic elements (MGE), including bacteriophages. MGE can overcome CRISPR …
mobile genetic elements (MGE), including bacteriophages. MGE can overcome CRISPR …
Structure-guided discovery of anti-CRISPR and anti-phage defense proteins
Bacteria use a variety of defense systems to protect themselves from phage infection. In turn,
phages have evolved diverse counter-defense measures to overcome host defenses. Here …
phages have evolved diverse counter-defense measures to overcome host defenses. Here …
Search for origins of anti-CRISPR proteins by structure comparison
Many bacterial and archaeal viruses encode anti-CRISPR proteins (Acrs) that specifically
inhibit CRISPR-Cas systems via various mechanisms. The majority of the Acrs are small …
inhibit CRISPR-Cas systems via various mechanisms. The majority of the Acrs are small …
Characterization of Ligilactobacillus salivarius CRISPR-Cas systems
Ligilactobacillus is a diverse genus among lactobacilli with phenotypes that reflect
adaptation to various hosts. CRISPR-Cas systems are highly prevalent within lactobacilli …
adaptation to various hosts. CRISPR-Cas systems are highly prevalent within lactobacilli …