The significant other: splicing by the minor spliceosome
The removal of non‐coding sequences, introns, from the mRNA precursors is an essential
step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns …
step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns …
[HTML][HTML] Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing
Alternative splicing contributes to the majority of protein diversity in higher eukaryotes by
allowing one gene to generate multiple distinct protein isoforms. It adds another regulation …
allowing one gene to generate multiple distinct protein isoforms. It adds another regulation …
Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
V Madan, D Kanojia, J Li, R Okamoto… - Nature …, 2015 - nature.com
Somatic mutations in the spliceosome gene ZRSR2—located on the X chromosome—are
associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of …
associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of …
[HTML][HTML] Structural studies of the spliceosome: bridging the gaps
The spliceosome is a multi-megadalton RNA–protein complex responsible for the removal of
non-coding introns from pre-mRNAs. Due to its complexity and dynamic nature, it has …
non-coding introns from pre-mRNAs. Due to its complexity and dynamic nature, it has …
Structure of the activated human minor spliceosome
INTRODUCTION Precursor messenger RNA (pre-mRNA) splicing, which involves the
removal of noncoding introns and the ligation of the coding exons, is achieved by the …
removal of noncoding introns and the ligation of the coding exons, is achieved by the …
Extreme genome diversity in the hyper-prevalent parasitic eukaryote Blastocystis
Blastocystis is the most prevalent eukaryotic microbe colonizing the human gut, infecting
approximately 1 billion individuals worldwide. Although Blastocystis has been linked to …
approximately 1 billion individuals worldwide. Although Blastocystis has been linked to …
Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated …
Biologically active proteins without stable ordered structure (ie, intrinsically disordered
proteins) are attracting increased attention. Functional repertoires of ordered and disordered …
proteins) are attracting increased attention. Functional repertoires of ordered and disordered …
[HTML][HTML] Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS
M Kamelgarn, J Chen, L Kuang, A Arenas… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Mutations
in the Fused in Sarcoma/Translocated in Liposarcoma (FUS/TLS) gene cause a subset of …
in the Fused in Sarcoma/Translocated in Liposarcoma (FUS/TLS) gene cause a subset of …
[HTML][HTML] Minor spliceosome and disease
B Verma, MV Akinyi, AJ Norppa, MJ Frilander - Seminars in cell & …, 2018 - Elsevier
Abstract The U12-dependent (minor) spliceosome excises a rare group of introns that are
characterized by a highly conserved 5′ splice site and branch point sequence. Several …
characterized by a highly conserved 5′ splice site and branch point sequence. Several …
RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators
B Li, S Liu, W Zheng, A Liu, P Yu, D Wu, J Zhou… - Nature …, 2024 - nature.com
A kink-turn (K-turn) is a three-dimensional RNA structure that exists in all three primary
phylogenetic domains. In this study, we developed the RIP-PEN-seq method to identify the …
phylogenetic domains. In this study, we developed the RIP-PEN-seq method to identify the …