The cardiovascular system in space: focus on in vivo and in vitro studies
R Baran, S Marchal, S Garcia Campos, E Rehnberg… - Biomedicines, 2021 - mdpi.com
On Earth, humans are subjected to a gravitational force that has been an important
determinant in human evolution and function. During spaceflight, astronauts are subjected to …
determinant in human evolution and function. During spaceflight, astronauts are subjected to …
The fight against cancer by microgravity: the multicellular spheroid as a metastasis model
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
Modeling the impact of microgravity at the cellular level: implications for human disease
A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …
on human physiology including muscle atrophy, reductions in bone density and immune …
Current knowledge about the impact of microgravity on gene regulation
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …
The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells
A spaceflight has enormous influence on the health of space voyagers due to the combined
effects of microgravity and cosmic radiation. Known effects of microgravity (μ g) on cells are …
effects of microgravity and cosmic radiation. Known effects of microgravity (μ g) on cells are …
A 3D‐bioprinted vascularized glioblastoma‐on‐a‐chip for studying the impact of simulated microgravity as a novel pre‐clinical approach in brain tumor therapy
Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors and
urgently requires the development of new therapeutic strategies. In this study, an innovative …
urgently requires the development of new therapeutic strategies. In this study, an innovative …
Satellite‐Based On‐Orbit Printing of 3D Tumor Models
X Mo, Y Zhang, Z Wang, X Zhou, Z Zhang… - Advanced …, 2024 - Wiley Online Library
Abstract Space three dimension (3D) bioprinting provides a precise and bionic tumor model
for evaluating the compound effect of the space environment on tumors, thereby providing …
for evaluating the compound effect of the space environment on tumors, thereby providing …
Cardiac function, structural, and electrical remodeling by microgravity exposure
MR Sy, JA Keefe, JP Sutton… - American Journal of …, 2023 - journals.physiology.org
Space medicine is key to the human exploration of outer space and pushes the boundaries
of science, technology, and medicine. Because of harsh environmental conditions related to …
of science, technology, and medicine. Because of harsh environmental conditions related to …
[HTML][HTML] The impact of spaceflight and simulated microgravity on cell adhesion
Microgravity induces a number of significant physiological changes in the cardiovascular,
nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell …
nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell …
Morphological and molecular changes in juvenile normal human fibroblasts exposed to simulated microgravity
The literature suggests morphological alterations and molecular biological changes within
the cellular milieu of human cells, exposed to microgravity (µ g), as many cell types …
the cellular milieu of human cells, exposed to microgravity (µ g), as many cell types …