Designing degradable hydrogels for orthogonal control of cell microenvironments

PM Kharkar, KL Kiick, AM Kloxin - Chemical Society Reviews, 2013 - pubs.rsc.org
Degradable and cell-compatible hydrogels can be designed to mimic the physical and
biochemical characteristics of native extracellular matrices and provide tunability of …

Materials engineering for immunomodulation

JA Hubbell, SN Thomas, MA Swartz - Nature, 2009 - nature.com
The engineering of materials that can modulate the immune system is an emerging field that
is developing alongside immunology. For therapeutic ends such as vaccine development …

Surface modification and property analysis of biomedical polymers used for tissue engineering

Z Ma, Z Mao, C Gao - Colloids and Surfaces B: Biointerfaces, 2007 - Elsevier
The response of host organism in macroscopic, cellular and protein levels to biomaterials is,
in most cases, closely associated with the materials' surface properties. In tissue …

Toward in situ tissue engineering: chemokine-guided stem cell recruitment

K Andreas, M Sittinger, J Ringe - Trends in biotechnology, 2014 - cell.com
Chemokines are potent stem cell homing and mobilization factors, and artificially increasing
the concentrations of specific chemokines at injury sites is an up-to-date strategy to …

Biomimetic delivery with micro‐and nanoparticles

SC Balmert, SR Little - Advanced materials, 2012 - Wiley Online Library
The nascent field of biomimetic delivery with micro‐and nanoparticles (MNP) has advanced
considerably in recent years. Drawing inspiration from the ways that cells communicate in …

An in vivo study of the host tissue response to subcutaneous implantation of PLGA-and/or porcine small intestinal submucosa-based scaffolds

MS Kim, HH Ahn, YN Shin, MH Cho, G Khang, HB Lee - Biomaterials, 2007 - Elsevier
An innate immune response is often found at the site of biomaterial implantation. Since the
effective use of biomaterials in vivo requires good biocompatibility and biofunctionality, it is …

Can anti‐migratory drugs be screened in vitro? A review of 2D and 3D assays for the quantitative analysis of cell migration

C Decaestecker, O Debeir… - Medicinal research …, 2007 - Wiley Online Library
The aim of the present review is to detail and analyze the pros and cons of in vitro tests
available to quantify the anti‐migratory effects of anti‐cancer drugs for their eventual use in …

Designing polymeric particles for antigen delivery

S De Koker, BN Lambrecht, MA Willart… - Chemical Society …, 2011 - pubs.rsc.org
By targeting dendritic cells, polymeric carriers in the nano to lower micron range constitute
very interesting tools for antigen delivery. In this critical review, we review how new …

Wound healing versus regeneration: role of the tissue environment in regenerative medicine

A Atala, DJ Irvine, M Moses, S Shaunak - MRS bulletin, 2010 - Springer
One of the major challenges in the field of regenerative medicine is how to optimize tissue
regeneration in the body by therapeutically manipulating its natural ability to form scar at the …

Biomimetic particles as therapeutics

RA Meyer, JC Sunshine, JJ Green - Trends in biotechnology, 2015 - cell.com
In recent years, there have been major advances in the development of novel nanoparticle-
and microparticle-based therapeutics. An emerging paradigm is the incorporation of …