Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

To achieve high compaction, most genomic DNA in eukaryotes is incorporated into
nucleosomes; however, regulatory factors and transcriptional machinery must gain access to …

Cooperative binding of transcription factors (TFs) to promoters and other regulatory regions
is essential for precise gene expression. The classical model of cooperativity requires direct …

Chromatin influences gene expression by restricting access of DNA binding proteins to their
cognate sites in the genome,,. Large-scale characterization of nucleosome positioning in …

The ATP-dependent chromatin remodeling complex SWI/SNF regulates transcription and
has been implicated in promoter nucleosome eviction. Efficient nucleosome disassembly by …

Summary Nucleosome-displacing-factors (NDFs) in yeast, similar to pioneer factors in
higher eukaryotes, can open closed chromatin and generate nucleosome-depleted regions …

Post-translational modification of nucleosomal histones has been suggested to contribute to
epigenetic transcriptional memory. We describe a case of transcriptional memory in yeast …

A challenge facing biology is to develop quantitative, predictive models of gene regulation.
Eukaryotic promoters contain transcription factor binding sites of differing affinity and …

Induction of the yeast PHO5 and PHO8 genes leads to a prominent chromatin transition at
their promoter regions as a prerequisite for transcription activation. Although induction of …

Eukaryotic gene expression starts off from a largely obstructive chromatin substrate that has
to be rendered accessible by regulated mechanisms of chromatin remodeling. The yeast …