In hippocampal pyramidal cells, a small subset of dendritic spines contain endoplasmic
reticulum (ER). In large spines, ER frequently forms a spine apparatus, while smaller spines …

Dendritic spines are small protrusions that receive most of the excitatory inputs to the
pyramidal neurons in the neocortex and the hippocampus. Excitatory neural circuits in the …

Super-resolution microscopy provides diffraction-unlimited optical access to the intricate
morphology of neurons in living brain tissue, resolving their finest structural details, which …

Abstract Information processing in the brain is controlled by quantal release of
neurotransmitters, a tightly regulated process. From ultrastructural analysis, it is known that …

Synaptic plasticity, the cellular basis for learning and memory, is mediated by a complex
biochemical network of signaling proteins. These proteins are compartmentalized in …

Background Dendritic spines are structural correlates of excitatory synapses in the brain.
Their density and structure are shaped by experience, pointing to their role in memory …

Background Dendritic spines are tiny protrusions found along the dendrites of neurons, and
their number is a measure of the density of synaptic connections. Altered density and …

Despite the significant advances in the development of automated image analysis
algorithms for the detection and extraction of neuronal structures, current software tools still …

The morphological analysis of dendritic spines is an important challenge for the
neuroscientific community. Most state-of-the-art techniques rely on user-supervised …

Analyzing the structure of dendritic spines presents a significant challenge to the brain
research community. Currently, the leading techniques rely on algorithms that require user …