DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

Isothermal amplification of nucleic acids

Y Zhao, F Chen, Q Li, L Wang, C Fan - Chemical reviews, 2015 - ACS Publications
Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

Rolling circle replication for biosensing, bioimaging, and biomedicine

S Yue, Y Li, Z Qiao, W Song, S Bi - Trends in Biotechnology, 2021 - cell.com
Rolling circle replication (RCR), including rolling circle amplification (RCA) and rolling circle
transcription (RCT), is an isothermal enzymatic reaction. Because of its high amplification …

[HTML][HTML] Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis

M Zhao, R Wang, K Yang, Y Jiang, Y Peng, Y Li… - … Pharmaceutica Sinica B, 2023 - Elsevier
RNAs are involved in the crucial processes of disease progression and have emerged as
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …

Challenges and perspectives of DNA nanostructures in biomedicine

A Keller, V Linko - Angewandte Chemie International Edition, 2020 - Wiley Online Library
DNA nanotechnology holds substantial promise for future biomedical engineering and the
development of novel therapies and diagnostic assays. The subnanometer‐level …

DNA nanotechnology from the test tube to the cell

YJ Chen, B Groves, RA Muscat, G Seelig - Nature nanotechnology, 2015 - nature.com
Abstract The programmability of Watson–Crick base pairing, combined with a decrease in
the cost of synthesis, has made DNA a widely used material for the assembly of molecular …

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

G Mahmoodi Chalbatani, H Dana… - International journal …, 2019 - Taylor & Francis
Cancer is one of the most complex diseases that has resulted in multiple genetic disorders
and cellular abnormalities. Globally, cancer is the most common health concern disease that …

DNA nanostructures: current challenges and opportunities for cellular delivery

A Lacroix, HF Sleiman - ACS nano, 2021 - ACS Publications
DNA nanotechnology has produced a wide range of self-assembled structures, offering
unmatched possibilities in terms of structural design. Because of their programmable …

Designer DNA nanostructures for therapeutics

S Jiang, Z Ge, S Mou, H Yan, C Fan - Chem, 2021 - cell.com
The field of structural DNA nanotechnology applies the programmability of Watson-Crick
base pairing to the construction of custom nanostructures that are prescribed by the …

Precision-guided missile-like DNA nanostructure containing warhead and guidance control for aptamer-based targeted drug delivery into cancer cells in vitro and in …

C Ouyang, S Zhang, C Xue, X Yu, H Xu… - Journal of the …, 2020 - ACS Publications
It is crucial to deliver anticancer drugs to target cells with high precision and efficiency. While
nanomaterials have been shown to enhance the delivery efficiency once they reach the …