Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

Control of metal homeostasis is essential for life in all kingdoms. In most prokaryotic
organisms the FUR (ferric uptake regulator) family of transcriptional regulators is involved in …

The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic
microorganisms and their hosts. It is also a pivotal component of the innate immune …

The bacteriostatic and bactericidal effects and the transcriptional response of
Mycobacterium tuberculosis to representative oxidative and nitrosative stresses were …

Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host
macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation …

The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin
repressor) family. In the presence of iron, it binds to a specific DNA sequence in the …

Iron is both an essential nutrient for the growth of microorganisms, as well as a dangerous
metal due to its capacity to generate reactive oxygen species (ROS) via the Fenton reaction …

Two‐component signal transduction systems (2‐CS) play an important role in bacterial
pathogenesis. In the work presented here, we have studied the effects of a mutation in the …

The role of iron in the growth and metabolism of M. tuberculosis and other mycobacteria is
discussed in relation to the acquisiton of iron from host sources, such as transferrin …

Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has
achieved a spread in the human population that is unmatched by any other bacterial …