Antibacterial drug discovery in the resistance era

ED Brown, GD Wright - Nature, 2016 - nature.com
The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …

Wall teichoic acids of gram-positive bacteria

S Brown, JP Santa Maria Jr… - Annual review of …, 2013 - annualreviews.org
The peptidoglycan layers of many gram-positive bacteria are densely functionalized with
anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial …

Envelope structures of Gram-positive bacteria

M Rajagopal, S Walker - Protein and sugar export and assembly in Gram …, 2017 - Springer
Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

[HTML][HTML] Wall teichoic acid function, biosynthesis, and inhibition

JG Swoboda, J Campbell, TC Meredith… - … : a European journal of …, 2010 - ncbi.nlm.nih.gov
One of the major differences between Gram-negative and Gram-positive organisms is the
presence or absence of an outer membrane (Figure 1). In Gram-negative organisms, the …

Make and break the alarmone: regulation of (p) ppGpp synthetase/hydrolase enzymes in bacteria

S Ronneau, R Hallez - FEMS microbiology reviews, 2019 - academic.oup.com
Bacteria use dedicated mechanisms to respond adequately to fluctuating environments and
to optimize their chances of survival in harsh conditions. One of the major stress responses …

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Structural perspective of peptidoglycan biosynthesis and assembly

AL Lovering, SS Safadi… - Annual review of …, 2012 - annualreviews.org
The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is
exploited as a target for the design of antibiotics. This pathway culminates in the production …

Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus

ML Atilano, PM Pereira, J Yates… - Proceedings of the …, 2010 - National Acad Sciences
The cell wall of Staphylococcus aureus is characterized by an extremely high degree of
cross-linking within its peptidoglycan (PGN). Penicillin-binding protein 4 (PBP4) is required …

Diversity in (p) ppGpp metabolism and effectors

K Liu, AN Bittner, JD Wang - Current opinion in microbiology, 2015 - Elsevier
Highlights•(p) ppGpp metabolic enzymes sense diverse stresses.•(p) ppGpp regulates
transcription initiation by targeting RNAP or GTP levels.•(p) ppGpp controls replication …

Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams

MA Farha, A Leung, EW Sewell, MA D'Elia… - ACS chemical …, 2013 - ACS Publications
Rising drug resistance is limiting treatment options for infections by methicillin-resistant
Staphylococcus aureus (MRSA). Herein we provide new evidence that wall teichoic acid …