Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis

H Tanjore, TS Blackwell… - American Journal of …, 2012 - journals.physiology.org
While the factors that regulate the onset and progression of idiopathic pulmonary fibrosis
(IPF) are incompletely understood, recent investigations have revealed that endoplasmic …

[HTML][HTML] Endoplasmic reticulum stress as a pro-fibrotic stimulus

H Tanjore, WE Lawson, TS Blackwell - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
Current evidence suggests a prominent role for endoplasmic reticulum (ER) stress and
activation of the unfolded protein response (UPR) in fibrotic conditions affecting a number of …

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

M Bueno, YC Lai, Y Romero, J Brands… - The Journal of …, 2015 - Am Soc Clin Investig
Although aging is a known risk factor for idiopathic pulmonary fibrosis (IPF), the pathogenic
mechanisms that underlie the effects of advancing age remain largely unexplained. Some …

[HTML][HTML] Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+ GZMB− CD8+ memory T cells and accumulation of type 2 memory T cells

M Terekhova, A Swain, P Bohacova, E Aladyeva… - Immunity, 2023 - cell.com
Extensive, large-scale single-cell profiling of healthy human blood at different ages is one of
the critical pending tasks required to establish a framework for the systematic understanding …

Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis

E Torres-González, M Bueno, A Tanaka… - American journal of …, 2012 - atsjournals.org
The incidence of idiopathic pulmonary fibrosis (IPF) increases with age. The mechanisms
that underlie the age-dependent risk for IPF are unknown. Based on studies that suggest an …

Viral infection and aging as cofactors for the development of pulmonary fibrosis

PK Naik, BB Moore - Expert review of respiratory medicine, 2010 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown origin and progression that
primarily affects older adults. Accumulating clinical and experimental evidence suggests that …

Epidemiology and management of common pulmonary diseases in older persons

KM Akgün, K Crothers, M Pisani - Journals of Gerontology …, 2012 - academic.oup.com
Pulmonary disease prevalence increases with age and contributes to morbidity and mortality
in older patients. Dyspnea in older patients is often ascribed to multiple etiologies such as …

La sexualidad en el adulto mayor

C Llanes Betancourt - Revista cubana de enfermería, 2013 - scielo.sld.cu
La sexualidad en el adulto mayor SciELO - Scientific Electronic Library Online vol.29
número3 Antecedentes conceptuales para las investigaciones en sistemas y servicios de …

A systematic review of the research progress of traditional Chinese medicine against pulmonary fibrosis: from a pharmacological perspective

S Qin, P Tan, J Xie, Y Zhou, J Zhao - Chinese Medicine, 2023 - Springer
Pulmonary fibrosis is a chronic progressive interstitial lung disease caused by a variety of
etiologies. The disease can eventually lead to irreversible damage to the lung tissue …

Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice

J Qu, SZ Yang, Y Zhu, T Guo, VJ Thannickal… - Journal of Experimental …, 2021 - rupress.org
Aging is a strong risk factor and an independent prognostic factor for progressive human
idiopathic pulmonary fibrosis (IPF). Aged mice develop nonresolving pulmonary fibrosis …