Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has
been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of …

Farnesoid X receptor (FXR), a metabolic nuclear receptor, plays critical roles in the
maintenance of systemic energy homeostasis and the integrity of many organs, including …

A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific
therapies. Here we show that glucose-mediated changes in gene expression largely persist …

Diabetes mellitus is a metabolic disease largely due to lifestyle and nutritional imbalance,
resulting in insulin resistance, hyperglycemia and vascular complications. Diabetic kidney …

The prevalence of kidney diseases has been increasing worldwide due to the aging
population and has results in an increased socioeconomic burden as well as increased …

Farnesoid X receptor (FXR) is an important regulator of bile acid, lipid, amino acid, and
glucose homeostasis, hepatic inflammation, regeneration, and fibrosis. FXR has been …

Diabetes is a highly prevalent metabolic disease that has emerged as a global challenge
due to its increasing prevalence and lack of sustainable treatment. Diabetic kidney disease …

The gut microbiome is increasingly recognized as a vital organ that participates in nutrient
acquisition, energy regulation and maintenance of human health. Targeted manipulation of …

Farnesoid X receptor (FXR) influences bile acid homeostasis and the progression of various
diseases. While the roles of hepatic and intestinal FXR in enterohepatic transport of bile …

Tissue factor (TF), which is a member of the cytokine receptor family, promotes coagulation
and coagulation-dependent inflammation. TF also exerts protective effects through unknown …