Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Copper (Cu) is a redox-active metal ion essential for most aerobic organisms. Cu serves as
a catalytic and structural cofactor for enzymes that function in energy generation, iron …

Copper, an essential micronutrient, controls multiple fundamental processes throughout all
forms of life, such as respiration, cell proliferation and neurotransmitter biosynthesis. High …

The mitochondrial inner membrane (IM) serves as the site for ATP production by hosting the
oxidative phosphorylation complex machinery most notably on the crista membranes …

Eukaryotic cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial
respiratory chain. COX is a multimeric enzyme formed by subunits of dual genetic origin …

Metals are essential elements of all living organisms. Among them, copper is required for a
multiplicity of functions including mitochondrial oxidative phosphorylation and protection …

Mitochondrial respiration is an energy producing process that involves the coordinated
action of several protein complexes embedded in the inner membrane to finally produce …

In high-throughput genome-level protein investigation efforts, such as Structural Genomics,
the systematic experimental characterization of metal-binding properties (ie, the …

Mitochondria are double-membrane organelles that contain their own genome, the
mitochondrial DNA (mtDNA), and reminiscent of its endosymbiotic origin. Mitochondria are …

Copper is an essential but potentially harmful trace element required in many enzymatic
processes involving redox chemistry. Cellular copper homeostasis in mammals is …