Copper is an important micronutrient required as a redox co-factor in the catalytic centers of
enzymes. However, free copper is a potential hazard because of its high chemical reactivity …

With the increased focus on intrinsically disordered proteins (IDPs) and their large
interactomes, the question about their specificity—or more so on their multispecificity—arise …

Highly charged intrinsically disordered proteins can form complexes with very high affinity in
which both binding partners fully retain their disorder and dynamics, exemplified by the …

Homologous recombination (HR) is a crucial pathway for double-stranded DNA break (DSB)
repair. During the early stages of HR, the newly generated DSB ends are processed to yield …

The ferric uptake regulator (Fur) protein is the founding member of the FUR superfamily of
metalloregulatory proteins that control metal homeostasis in bacteria. FUR proteins regulate …

The interactions between proteins and their specific DNA sequences are the basis of many
cellular processes. Hence, developing methods to build an atomic level picture of these …

Binding and unbinding of transcription regulators at operator sites constitute a primary
mechanism for gene regulation. While many cellular factors are known to regulate their …

The binding of transcription factors (TFs) to DNA controls most aspects of cellular function,
making the understanding of their binding kinetics imperative. The standard description of …

In the last 20 years, the use of electron paramagnetic resonance (EPR) has made a
pronounced and lasting impact in the field of structural biology. The advantage of EPR …

Recent work has demonstrated concentration-dependent unbinding rates of proteins from
DNA, using fluorescence visualization of the bacterial nucleoid protein Fis [Graham et …