The eye and lens represent excellent models to understand embryonic development at
cellular and molecular levels. Initial 3D formation of the eye depends on a reciprocal …

The prevalent model for cataract formation in the eye lens posits that damaged crystallin
proteins form light-scattering aggregates. The α-crystallins are thought to counteract this …

Mouse mutants are a long-lasting, valuable tool to identify genes underlying eye diseases,
because the absence of eyes, very small eyes and severely affected, cataractous eyes are …

Pediatric cataracts are observed in 1–15 per 10,000 births with 10–25% of cases attributed
to genetic causes; autosomal dominant inheritance is the most commonly observed pattern …

Purpose: The gene for Eph-receptor tyrosinekinase-type A2 (EPHA2) has been shown to be
involved in the pathogenesis of age-related cataract (ARC). The aim of this study was to …

Loss-of-function alleles are a pertinent source of genetic variation with the potential to
contribute to adaptation. Cave-adapted organisms exhibit striking loss of ancestral traits …

The eye lens displays a variety of phenotypes in the wake of genetic modifications or
environmental influences. Therefore, a high-resolution in vivo imaging method for the lens is …

Purpose.: To evaluate racial differences in nuclear and cortical lens opacity incidence and
progression over a 2-year period in an older American population. Methods.: Prospective …

Cataracts are the major eye disorder and have been associated mainly with mutations in
lens-specific genes, but cataracts are also frequently associated with complex syndromes. In …

Background Age-related cataract (ARC) is the main cause of blindness in older individuals
but its specific pathogenic mechanism is unclear. This study aimed to identify differentially …