Late-stage diversification of natural products is an efficient way to generate natural product
derivatives for drug discovery and chemical biology. Benefiting from the development of site …

Natural products are structurally and biologically interesting metabolites, but they have been
isolated in minute amounts. The syntheses of such natural products help in obtaining them …

A mild and selective C (sp3)− H aerobic oxidation enabled by decatungstate photocatalysis
has been developed. The reaction can be significantly improved in a microflow reactor …

The selective oxyfunctionalization of isolated sp3 C–H bonds in complex molecules
represents a formidable challenge in organic chemistry. Here, we describe a rational …

Artemisinin isolated from the aerial parts of Artemisia annua L. is a promising and potent
antimalarial drug which has a remarkable activity against chloroquine-resistant and …

The isolation of artemisinin from the traditional medicinal herb qīng hāo (Artemisia annua),
its characterization as a peroxide and preparation of the derivatives dihydroartemisinin …

Intrusion into the C–H chemical space of natural products through the strategic deployment
of C–H functionalization reactions could lead to incredibly new molecular diversities with an …

To explore novel high efficiency and low toxicity antitumor agents, a series of
dihydroartemisinin-cinnamic acid ester derivatives modified on C-12 and/or C-9 position (s) …

The fungal and bacterial transformation of terpenoids derived from plant essential oils,
especially the sesquiterpenoid artemisinin from Artemisia annua, has produced several new …

Biotransfomation has been increasingly utilized as a tool to generate pharmaceutical lead
compounds from natural products in recent years. A wide variety of natural pruducts …