The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation

J Teppan, J Schwanzer, S Rittchen… - Frontiers in …, 2024 - frontiersin.org
Introduction Macrophage dysfunction is a common feature of inflammatory disorders such as
asthma, which is characterized by a strong circadian rhythm. Methods and results We …

Altered circadian gene expression in primary human airway epithelial cells in asthma

WT Powell, LV Clark, LM Rich… - ERJ Open …, 2024 - Eur Respiratory Soc
Cellular circadian rhythms regulate multiple processes and have been hypothesized to
influence epithelial function in asthma.[1] Clinical studies demonstrate increased risk for …

The impact of physiological variability on asthma diagnosis and management

R Wang - 2024 - search.proquest.com
One in 11 people in the UK are diagnosed with asthma but about a third who are treated for
asthma do not have asthma at all, and many with asthma never receive a diagnosis and …

REV-ERBα agonist SR10067 attenuates Th2 cytokine-mediated barrier dysfunction in human bronchial epithelial cells

SK Duraisamy, IK Sundar - Clinical Science, 2024 - portlandpress.com
Allergens and Th2 cytokines affect the homeostatic environment in the airways, leading to
increased mucus production by goblet cells associated with altered adherens junctional …