Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall
prognosis that has remained virtually unchanged for many decades. Currently, prevention or …

The concept of epithelial-mesenchymal transition (EMT), a process where cells change their
epithelial towards a mesenchymal phenotype, has gained overwhelming attention …

Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal
prognosis despite current best therapies; therefore new treatment strategies are urgently …

Multimodal, genome-wide characterization of epigenetic and genetic information in
circulating cell-free DNA (cfDNA) could enable more sensitive early cancer detection, but it …

In early pancreatic carcinogenesis, TGFβ acts as a tumor suppressor due to its growth-
inhibitory effects in epithelial cells. However, in advanced disease, TGFβ appears to …

Background: There is evidence that tumour–stroma interactions have a major role in the
neoplastic progression of pancreatic ductal adenocarcinoma (PDAC). Tumour budding is …

Understanding the initiation and progression of pancreatic ductal adenocarcinoma (PDAC)
may provide therapeutic strategies for this deadly disease. Recently, we and others made …

The transforming growth factor‐β (TGF‐β) signaling pathway mediates various biological
functions, and its dysregulation is closely related to the occurrence of malignant tumors …

Purpose: We investigated the role of the human endogenous retrovirus type K (HERV-K)
envelope (env) gene in pancreatic cancer. Experimental Design: shRNA was employed to …

Early detection of gastrointestinal tumors improves patient survival. However, patients with
these tumors are typically diagnosed at an advanced stage and have poor prognosis. The …