A Khaminets, C Behl, I Dikic - Trends in cell biology, 2016 - cell.com
Selective autophagy regulates the abundance of specific cellular components via a specialized arsenal of factors, termed autophagy receptors, that target protein complexes …
RE Thompson, TW Muir - Chemical reviews, 2019 - ACS Publications
Protein semisynthesis—defined herein as the assembly of a protein from a combination of synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …
FX Theillet, A Binolfi, T Frembgen-Kesner… - Chemical …, 2014 - ACS Publications
It has long been axiomatic that a protein's structure determines its function. Intrinsically disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …
J Zhang, X Li, JD Li - Frontiers in neuroscience, 2019 - frontiersin.org
Parkinson's disease is the second most common neurodegenerative disorder. Although the pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …
HE Allen Reish, DG Standaert - Journal of Parkinson's …, 2015 - content.iospress.com
Abstract Alpha-synuclein (α-syn) is central to the pathogenesis of Parkinson disease (PD). Gene duplications, triplications and point mutations in SNCA1, the gene encoding α-syn …
SX Pancoe, YJ Wang, M Shimogawa, RM Perez… - Journal of molecular …, 2022 - Elsevier
Fibrillar aggregates of the α-synuclein (αS) protein are the hallmark of Parkinson's Disease and related neurodegenerative disorders. Characterization of the effects of mutations and …
F Le Guerroué, RJ Youle - Cell Death & Differentiation, 2021 - nature.com
Ubiquitin signaling is a sequence of events driving the fate of a protein based on the type of ubiquitin modifications attached. In the case of neurodegenerative diseases, ubiquitin …
α-Synuclein amyloid aggregation is a defining molecular feature of Parkinson's disease, Lewy body dementia, and multiple system atrophy, but can also be found in other …
Synuclein aggregation in neuronal cells is the primary underlying cause of synucleinopathies. Changes in gene expression patterns, structural modifications, and …