Understanding temporal integration by the brain is expected to be among the premier topics
to unite systems, cellular, computational, and cognitive neuroscience over the next decade …

BACKGROUND: Attentional deficits accompany many psychiatric disorders, underscoring
the need for rodent models of attention to screen novel therapeutic agents and characterize …

Experiments 1 and 2 address the controversy regarding the reliability of methamphetamine
effects on interval timing. A temporal discrimination procedure was used, in which the rats …

Previous studies from this laboratory have demonstrated that a variety of psychostimulant
drugs can improve the performance of rats trained in a 2-choice stimulus detection task in …

Rationale Attentional deficits occur in a range of neuropsychiatric disorders, such as
schizophrenia and attention deficit hyperactivity disorder. Psychostimulants are one of the …

The effects of nicotine on sustained attention were tested in F344× BN male rats when they
were chronologically middle and old aged. The rats (n= 11) were trained in a two-choice …

Psychostimulants, such as amphetamine, are widely used to treat attentional deficits. In
humans, response to dopaminergic medications is complex with improvement often …

Previous work has demonstrated that drugs increasing brain concentrations of acetylcholine
can enhance cognition in aging and brain-damaged organisms. The present study assessed …

Relevance of a neutral cue for performance in a two-choice visuospatial detection task was
examined. Nine rats were trained, 5 with short intertrial interval (ITI) and 4 with long ITI, to …

Rewarding doses of amphetamine increase the amplitude, duration, and frequency of
dopamine transients in the ventral striatum. Debate continues at the behavioral level about …