The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action …
R Shechter, A London, M Schwartz - Nature Reviews Immunology, 2013 - nature.com
Complex barriers separate immune-privileged tissues from the circulation. Here, we propose that cell entry to immune-privileged sites through barriers composed of tight junction …
Most higher animals require sight for survival, yet even minor distortions of the visual axis can cause blindness. For this reason, intraocular inflammation is incompatible with good …
IM Wormstone, L Wang, CSC Liu - Experimental eye research, 2009 - Elsevier
Posterior Capsule Opacification (PCO) is the most common complication of cataract surgery. At present the only means of treating cataract is by surgical intervention, and this initially …
Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in …
It has been over 60 years since the phrase immune privilege was used by Sir Peter Medawar to describe the lack of an immune response against allografts placed into the …
IM Wormstone, S Tamiya, I Anderson… - … ophthalmology & visual …, 2002 - arvojournals.org
purpose. To study the role of TGF-β2 in posterior capsule opacification (PCO) and to determine whether CAT-152 (lerdelimumab), a fully human monoclonal antibody that …
IM Wormstone - Experimental eye research, 2002 - Elsevier
Posterior capsule opacification (PCO) is the most common complication of cataract surgery. At present the only means of treating cataract is by surgical intervention, and this initially …
purpose. To examine the normal murine corneal stroma for the presence of bone marrow- derived leukocytes. methods. Wholemounts of paraformaldehyde-fixed corneal stroma from …