The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Cardiac fibroblasts account for about 75% of all cardiac cells, but because of their small size
contribute only∼ 10–15% of total cardiac cell volume. They play a crucial role in cardiac …

Rationale: Cardiac fibrosis contributes to pathogenesis of atrial fibrillation (AF), which is the
most commonly sustained arrhythmia and a major cause of morbidity and mortality. Although …

Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), remains an
unresolved problem in most forms of heart disease. In order to be successful in preventing …

Background—Fibroblast proliferation and differentiation are central in atrial fibrillation (AF)–
promoting remodeling. Here, we investigated fibroblast regulation by Ca2+-permeable …

C-type natriuretic peptide (CNP) is an autocrine and paracrine mediator released by
endothelial cells, cardiomyocytes and fibroblasts that regulates vital physiological functions …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …

Transient receptor potential (TRP) channels are nonselective cationic channels that are
generally Ca2+ permeable and have a heterogeneous expression in the heart. In the …

The transient receptor potential (TRP) channel superfamily consists of 28 mammalian cation
channels and is expressed in almost every tissue, including the heart and vasculature; most …

Natriuretic peptides (NPs), including atrial, brain and C‐type natriuretic peptides (ANP, BNP
and CNP), bind two classes of cell surface receptors: the guanylyl cyclase‐linked A and B …