The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …

The steroid hormone ecdysone is the central regulator of insect developmental transitions.
Recent new advances in our understanding of ecdysone action have relied heavily on the …

Cellular memory is provided by two counteracting groups of chromatin proteins termed
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …

Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys
27 (H3K27ac) are histone modifications that are highly enriched over the body of actively …

The KMT2 (lysine methyltransferase) family of histone modifying proteins play essential
roles in regulating developmental pathways, and mutations in the genes encoding these …

Covalent modification of histones on chromatin is a dynamic mechanism by which various
nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented …

In the last few years, the discovery of lysine and arginine methylation in histones and other
proteins and the enzymes that carry out these posttranslational modifications has added a …

Intellectual disability (ID) disorders are genetically and phenotypically highly heterogeneous
and present a major challenge in clinical genetics and medicine. Although many genes …

Kleefstra syndrome, caused by haploinsufficiency of euchromatin histone methyltransferase
1 (EHMT1), is characterized by intellectual disability (ID), autism spectrum disorder (ASD) …

Eukaryotic genomes are packaged into chromatin, a highly organized structure consisting of
DNA and histone proteins. All nuclear processes take place in the context of chromatin …