Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …

In the past decade, multicomponent reactions have experienced a renaissance as powerful
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …

Abstract Manganese (I)‐catalyzed C− H alkynylations with organic halides occurred with
unparalleled substrate scope, and thus enabled step‐economical C− H functionalizations …

Histidine (His) carries a unique heteroaromatic imidazole side chain and plays irreplaceable
functional roles in peptides and proteins. Existing strategies for site-selective histidine …

New methods capable of effecting cyclization, and forming novel three-dimensional
structures while maintaining favourable physicochemical properties are needed to facilitate …

The site‐selective functionalization of unactivated C (sp3)− H bonds remains one of the
greatest challenges in organic synthesis. Herein, we report on the site‐selective δ‐C (sp3) …