Perspectives on primary blast injury of the brain: translational insights into non-inertial low-intensity blast injury

HR Siedhoff, S Chen, H Song, J Cui, I Cernak… - Frontiers in …, 2022 - frontiersin.org
Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild”
and frequently caused by non-impact blast exposures. Experimental models were …

Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice

C Li, S Chen, HR Siedhoff, DA Grant, P Liu… - Acta Neuropathologica …, 2023 - Springer
Mild traumatic brain injury (mTBI) induced by low-intensity blast (LIB) is a serious health
problem affecting military service members and veterans. Our previous reports using a …

The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma

GA Elder, MA Gama Sosa, R De Gasperi… - International Journal of …, 2024 - mdpi.com
Blast-induced neurotrauma has received much attention over the past decade. Vascular
injury occurs early following blast exposure. Indeed, in animal models that approximate …

Mitochondrial dysfunction after repeated mild blast traumatic brain injury is attenuated by a mild mitochondrial uncoupling prodrug

WB Hubbard, HJ Vekaria, GV Velmurugan… - Journal of …, 2023 - liebertpub.com
Mild traumatic brain injury (mTBI) results in impairment of brain metabolism, which is
propagated by mitochondrial dysfunction in the brain. Mitochondrial dysfunction has been …

Shock wave physics as related to primary non-impact blast-induced traumatic brain injury

B Rutter, H Song, RG DePalma, G Hubler… - Military …, 2021 - academic.oup.com
Introduction Blast overpressure exposure, an important cause of traumatic brain injury (TBI),
may occur during combat or military training. TBI, most commonly mild TBI, is considered a …

Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins …

S Chen, HR Siedhoff, H Zhang, P Liu… - Neurobiology of …, 2022 - Elsevier
Neurocognitive consequences of blast-induced traumatic brain injury (bTBI) pose significant
concerns for military service members and veterans with the majority of “invisible injury.” …

Effect of mild blast-induced TBI on dendritic architecture of the cortex and hippocampus in the mouse

WA Ratliff, RF Mervis, BA Citron, B Schwartz… - Scientific reports, 2020 - nature.com
Traumatic brain injury (TBI) has been designated as a signature injury of modern military
conflicts. Blast trauma, in particular, has come to make up a significant portion of the TBIs …

Quantitative proteomic profiling in brain subregions of mice exposed to open-field low-intensity blast reveals position-dependent blast effects

M Jackson, S Chen, P Liu, M Langenderfer, C Li… - Shock Waves, 2024 - Springer
The neurological consequences of combat blast-induced neurotrauma (BINT) pose
important clinical concerns for military service members and veterans. Previous studies have …

[HTML][HTML] Inhibition of glutamatergic neurons in layer II/III of the medial prefrontal cortex alleviates paclitaxel-induced neuropathic pain and anxiety

J Cao, X Liu, JX Liu, S Zhao, YX Guo, GY Wang… - European Journal of …, 2022 - Elsevier
Paclitaxel-treated patients frequently experience chemotherapy-induced peripheral
neuropathy (CIPN) and mood changes, such as anxiety. Layer II/III of the medial prefrontal …

Axonopathy precedes cell death in ocular damage mediated by blast exposure

NA Boehme, A Hedberg-Buenz, N Tatro, M Bielecki… - Scientific reports, 2021 - nature.com
Traumatic brain injuries (TBI) of varied types are common across all populations and can
cause visual problems. For military personnel in combat settings, injuries from blast …