Germinal center (GC) B cells are the source of the high-affinity, class-switched antibodies
required for protective immunity. The unique biology of GC B cells involves iterative rounds …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Ten-eleven translocation proteins (TET1-3) are dioxygenases that oxidize 5-
methyldeoxycytosine, thus taking part in passive and active demethylation. TETs have …

The mammalian DNA methylation landscape is established and maintained by the
combined activities of the two key epigenetic modifiers, DNA methyltransferases (DNMT) …

B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although previous
studies have shown many genetic polymorphisms associated with B-cell activation in …

Simple Summary Programmed cell death ligand 1 (PD-L1) is an essential immune
checkpoint molecule that helps tumor cells to escape the immune surveillance. The aim of …

The epigenome bridges environmental factors and the genome, fine-tuning the process of
gene transcription. Physiological programs, including the development, maturation and …