Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …

A dysregulated host response to infection causes organ dysfunction in sepsis and septic
shock, two potentially fatal diseases. They continue to be major worldwide health burdens …

Background Organ congestion is a mediator of adverse outcomes in critically ill patients.
Point-Of-Care ultrasound (POCUS) is widely available and could enable clinicians to detect …

Rationale: Prior sepsis studies evaluating antibiotic timing have shown mixed results.
Objectives: To evaluate the association between antibiotic timing and mortality among …

Importance Norepinephrine is currently recommended as the first-line vasopressor in septic
shock; however, early vasopressin use has been proposed as an alternative. Objective To …

Purpose We assessed the effects of a protocol restricting resuscitation fluid vs. a standard
care protocol after initial resuscitation in intensive care unit (ICU) patients with septic shock …

Sepsis is a common clinical entity causing thousands of deaths and costing billions of
healthcare dollars annually in the US alone [1–4]. Further, sepsis and septic shock represent …

Objectives: Presenting symptoms in patients with sepsis may influence rapidity of diagnosis,
time-to-antibiotics, and outcome. We tested the hypothesis that vague presenting symptoms …

Background Septic shock comprises a heterogeneous population, and individualized
resuscitation strategy is of vital importance. The study aimed to identify subclasses of septic …

While it is well known that bacterial infection is the predominant cause of sepsis, the
molecular pathophysiology of this clinical syndrome remains ill-defined. In this Research …