Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Objectives P4 Medicine is based on a proactive approach for clinical patient care
incorporating the four “pillars” of prediction, prevention, personalization, and participation for …

Existing research indicates that different types of meat have varying effects on health and
aging, but the specific causal relationships remain unclear. This study aimed to explore the …

Background Centenarians and supercentenarians with exceptional longevity are excellent
models for research towards improvements of healthy life expectancy. Extensive research …

Over the past decade, genome-scale molecular profiling of large childhood cancer
survivorship cohorts has led to unprecedented advances in our understanding of the genetic …

During aging, several tissues and biological systems undergo a progressive decline in
function, leading to age-associated diseases such as neurodegenerative, inflammatory …

Importance Certain cancer therapies are risk factors for epigenetic age acceleration (EAA)
among survivors of childhood cancer, and EAA is associated with chronic health conditions …

Here, we found that functionally active mitochondria isolated from the brain of NMRI donor
mice and administrated intranasally to recipient mice penetrated the brain structures in a …

Aging is a gradual process that occurs over time which leads to a progressive decline of
cells and tissues. Telomere shortening, genetic instability, epigenetic alteration, and the …

The article gives a brief description of geroprotection and rejuvenation methods known to
date, presenting their main mechanisms and limitations. To overcome the main limitations of …