Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Microglia are the predominant immune cells of the central nervous system (CNS) that exert
key physiological roles required for maintaining CNS homeostasis, notably in response to …

Clinical studies examining the potential of anti-inflammatory agents, specifically of
minocycline, as a treatment for depression has shown promising results. However …

As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …

Depression remains one of the most prevalent psychiatric disorders, with many patients not
responding adequately to available treatments. Chronic or early-life stress is one of the key …

Cannabidiol (CBD) is the most abundant non-psychoactive component of cannabis; it
displays a very low affinity for cannabinoid receptors, facilitates endocannabinoid signaling …

Major depressive disorder is the main cause of disability worldwide with imperfect treatment
options. However, novel therapeutic approaches are currently discussed, from augmentation …

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Background and purpose Minocycline is a broad‐spectrum antibiotic, effective as a chronic
treatment for recurrent bacterial infections. Beyond its antibiotic action, minocycline also has …