Although they were discovered more than 50 years ago, caveolae have remained enigmatic
plasmalemmal organelles. With their characteristic “flasklike” shape and virtually ubiquitous …

We found that caveolin-2 is targeted to the surface of lipid droplets (Fujimoto, T., Kogo, H.,
Ishiguro, K., Tauchi, K., and Nomura, R.(2001) J. Cell Biol. 152, 1079–1085) and …

Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a …

Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids
that are involved in the lateral compartmentalization of molecules at the cell surface …

Caveolin-3, a muscle-specific caveolin-related protein, is the principal structural protein of
caveolae membrane domains in striated muscle cells. Recently, we identified a novel …

Transforming growth factor-β (TGF-β) signaling proceeds from the cell membrane to the
nucleus through the cooperation of the type I and II serine/threonine kinase receptors and …

Caveolin‐1 is a principal component of caveolae membranes in vivo. Caveolin‐1 mRNA
and protein expression are lost or reduced during cell transformation by activated …

Abstract The Src-family kinases (SFKs), an intracellularly located group of non-receptor
tyrosine kinases are involved in oncogenesis. The importance of SFKs has been implicated …

Caveolins form interlocking networks on the cytoplasmic face of caveolae. The
cytoplasmically directed N and C termini of caveolins are separated by a central …

Senescent human diploid fibroblasts do not respond to growth factors like epidermal growth
factor (EGF), although they have a normal level of receptors and downstream signaling …