Purpose—Much has transpired since the last scientific statement on pediatric stroke was
published 10 years ago. Although stroke has long been recognized as an adult health …

Purpose—To critically review and evaluate the science behind individual eligibility criteria
(indication/inclusion and contraindications/exclusion criteria) for intravenous recombinant …

Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …

Methods The TIPS study was an international multicenter, dose-adaptive, phase 1 cohort
study. Study design spanned several years with input from members of the International …

Background For childhood-onset arterial ischaemic stroke (AIS), treatment trials are lacking
and practices vary from country to country and centre to centre. We aimed to describe …

Background and Purpose—Data regarding the safety and efficacy of intravenous tPA (tissue-
type plasminogen activator) in childhood acute arterial ischemic stroke are inadequate. The …

Stroke occurs across the lifespan with unique issues in the fetus, neonate, and child. The
past decade has seen substantial advances in paediatric stroke research and clinical care …

Brain ischemia affects all ages, from neonates to the elderly population, and is a leading
cause of mortality and morbidity. Multiple preclinical rodent models involving different ages …

Objective Intravenous thrombolysis and endovascular therapy (IVT/EVT) are evidence‐
based treatments for adults with arterial ischemic stroke (AIS). However, randomized …

Background and Purpose—In adult stroke, the advent of thrombolytic therapy led to the
development of primary stroke centers capable to diagnose and treat patients with acute …