Single-domain antibodies as building blocks for novel therapeutics

D Saerens, GH Ghassabeh, S Muyldermans - Current opinion in …, 2008 - Elsevier
Antibodies are large and complex molecules, with two identical parts that bind
independently of each other onto the antigen and the third part of the molecule that dictates …

Survey of the year 2006 commercial optical biosensor literature

RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2007 - Wiley Online Library
We identified 1219 articles published in 2006 that described work performed using
commercial optical biosensor platforms. It is interesting to witness how the biosensor market …

Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment

BR Zhou, KNS Yadav, M Borgnia, J Hong… - Nature …, 2019 - nature.com
Genomic DNA in eukaryotes is organized into chromatin through association with core
histones to form nucleosomes, each distinguished by their DNA sequences and histone …

Targeted protein degradation using intracellular antibodies and its application to neurodegenerative disease

JA Benn, AS Mukadam, WA McEwan - Seminars in Cell & Developmental …, 2022 - Elsevier
Antibodies mediate the majority of their effects in the extracellular domain, or in intracellular
compartments isolated from the cytosol. Under a growing list of circumstances, however …

Natural catalytic antibodies in norm and in HIV-infected patients

GA Nevinsky - Understanding HIV/AIDS Management and Care …, 2011 - books.google.com
Antibodies (Abs) have been first characterized as proteins which are produced by the
immune system and have a sole function of binding other molecules, called antigens, with …

Harnessing SLE autoantibodies for intracellular delivery of biologic therapeutics

RE Gordon, JF Nemeth, S Singh, RB Lingham… - Trends in …, 2021 - cell.com
Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for
biomedical research and the pharmaceutical industry. Approximately two-thirds of disease …

Cellular internalization mechanism and intracellular trafficking of filamentous M13 phages displaying a cell-penetrating transbody and TAT peptide

A Kim, TH Shin, SM Shin, CD Pham, DK Choi… - PloS one, 2012 - journals.plos.org
Cellular internalization of bacteriophage by surface-displayed cell penetrating peptides has
been reported, though the underlying mechanism remains elusive. Here we describe in …

DNA-hydrolysing activity of IgG antibodies from the sera of patients with schizophrenia

EA Ermakov, LP Smirnova… - Open …, 2015 - royalsocietypublishing.org
It is believed that damage to the membranes of brain cells of schizophrenia (SCZ) patients
induces the formation of autoantigens and autoantibodies. Nevertheless, the importance of …

Transgenic resistance

F Cillo, P Palukaitis - Advances in virus research, 2014 - Elsevier
Transgenic resistance to plant viruses is an important technology for control of plant virus
infection, which has been demonstrated for many model systems, as well as for the most …

A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells

KJ Park, SH Lee, TI Kim, HW Lee, CH Lee, EH Kim… - Cancer research, 2007 - AACR
Tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) induces apoptotic
cell death in a variety of tumor cells without significant cytotoxicity on normal cells. However …