Individualizing cancer therapy for molecular targeted inhibitors requires a new class of
molecular profiling technology that can map the functional state of the cancer cell signal …

New biomarkers are urgently needed to accelerate efforts in developing new drugs and
treatments of known diseases. New clinical and translational proteomics studies emerge …

In most hospitals word-wide, histopathological cancer diagnosis is currently based on
formalin-fixed and paraffin-embedded (FFPE) tissues. In the last few years new approaches …

In recent years, new anticancer therapies have accompanied the classical approaches of
surgery and radio-and chemotherapy. These new forms of treatment aim to inhibit specific …

The proteome is highly variable and differs from cell to cell. The reasons are
posttranslational modifications, splice variants, and polymorphisms. Techniques like next …

The current transition in cancer therapy from general treatment approaches, based mainly
on chemotherapy and radiotherapy, to more directed approaches that aim to inhibit specific …

Very often dysfunctional aspects of various signalling networks are found to be associated
with human diseases and disorders. The major characteristics of signal transduction …

Background Reverse phase protein arrays (RPPA) emerged as a useful experimental
platform to analyze biological samples in a high-throughput format. Different signal detection …

Viruses have developed numerous and elegant strategies to manipulate the host cell
machinery to establish a productive infectious cycle. The interaction of viral proteins with …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of late
symptoms and resistance to chemotherapy and radiation therapy. We have investigated the …