The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous
system (PNS), is a critical feature in the context of peripheral nerve regeneration following …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Traumatic injury to peripheral nerves results in the loss of neural functions. Recovery by
regeneration depends on the cellular and molecular events of Wallerian degeneration that …

Axotomy or crush of a peripheral nerve leads to degeneration of the distal nerve stump
referred to as Wallerian degeneration (WD). During WD a microen‐vironment is created that …

Schwann cell incredible plasticity is a hallmark of the utmost importance following nerve
damage or in demyelinating neuropathies. After injury, Schwann cells undergo …

Dedifferentiation of myelinating Schwann cells is a key feature of nerve injury and
demyelinating neuropathies. We review recent evidence that this dedifferentiation depends …

Wallerian degeneration (WD) is the set of molecular and cellular events by which
degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the …

Schwann cell myelination depends on Krox-20/Egr2 and other promyelin transcription
factors that are activated by axonal signals and control the generation of myelin-forming …

Neuregulins comprise a family of epidermal growth factor-like ligands that interact with ErbB
receptor tyrosine kinases to control many aspects of neural development. One of the most …

Schwann cells are a regenerative cell type. Following nerve injury, a differentiated
myelinating Schwann cell can dedifferentiate and regain the potential to proliferate. These …