Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

WNT/β-catenin signaling is involved in many physiological processes. Its implication in
embryonic development, cell migration, and polarization has been shown. Nevertheless …

Wnt signaling is one of the key signaling pathways that govern numerous physiological
activities such as growth, differentiation and migration during development and …

Wnt signaling plays an essential role in the initiation and progression of various types of
cancer. Besides, the Wnt pathway components have been established as reliable …

Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

There is documented sex disparity in cutaneous melanoma incidence and mortality,
increasing disproportionately with age and in the male sex. However, the underlying …

Abstract HSP90 (heat shock protein 90) is an ATP-dependent molecular chaperone involved
in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed …

Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a
diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells …

Immune checkpoint inhibitors (ICIs) show promise, but most patients do not respond. We
identify and validate biomarkers from extracellular vesicles (EVs), allowing non-invasive …