Epidermal growth factor, from gene organization to bedside

F Zeng, RC Harris - Seminars in cell & developmental biology, 2014 - Elsevier
In 1962, epidermal growth factor (EGF) was discovered by Dr. Stanley Cohen while studying
nerve growth factor (NGF). It was soon recognized that EGF is the prototypical member of a …

The epidermal growth factor receptor critically regulates endometrial function during early pregnancy

MJ Large, M Wetendorf, RB Lanz, SM Hartig… - PLoS …, 2014 - journals.plos.org
Infertility and adverse gynecological outcomes such as preeclampsia and miscarriage
represent significant female reproductive health concerns. The spatiotemporal expression of …

Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles

J Dackor, KM Caron, DW Threadgill - Genetics, 2009 - academic.oup.com
Embryos lacking an epidermal growth factor receptor (EGFR) exhibit strain-specific defects
in placental development that can result in mid-gestational embryonic lethality. To determine …

Rhythm of the First Language: Dynamics of Extracellular Vesicle-Based Embryo–Maternal Communication in the Pre-Implantation Microenvironment

K Godakumara, PR Heath, A Fazeli - International Journal of Molecular …, 2023 - mdpi.com
One of the most critical steps in mammalian reproduction is implantation. Embryos with an
impaired capacity for embryo–maternal crosstalk are thought to have a reduced potential for …

Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age

DRV Edwards, R Romero, JP Kusanovic… - The Journal of …, 2011 - Taylor & Francis
Objective. To examine the association between maternal and fetal genetic variants and
small-for-gestational-age (SGA). Methods. A case–control study was conducted in patients …

STAT5 is activated by epidermal growth factor and induces proliferation and invasion in trophoblastic cells

S Ospina-Prieto, W Chaiwangyen… - Reproductive …, 2015 - journals.sagepub.com
Epidermal growth factor (EGF) is expressed by decidual and trophoblast cells and
influences manifold cellular functions during embryo implantation. Thus far, signaling of EGF …

A partial genome scan to identify quantitative trait loci affecting birthweight in Kermani sheep

AK Esmailizadeh - Small ruminant research, 2010 - Elsevier
The aim of this study was to map quantitative trait loci (QTL) underlying variation in
birthweight (BWT) in a population of Kermani sheep, an indigenous fat-tailed sheep breed in …

Polymorphism in the epidermal growth factor gene is associated with pre‐eclampsia and low birthweight

T Chenthuran, GH Galhenagey… - Journal of Obstetrics …, 2014 - Wiley Online Library
Aim We have previously reported that polymorphism in the epidermal growth factor (EGF)
gene is associated with pre‐eclampsia and birthweight based on case–control association …

Cytokines regulating trophoblast invasion

JS Fitzgerald, C Abad, AM Alvarez… - Advances in …, 2011 - content.iospress.com
Pregnancy is personally special to every woman expecting a child, but is also interesting
from the perspective of an immunologist. During a physiological pregnancy, the mother's …

A study of three candidate genes for pre‐eclampsia in a Sinhalese population from Sri Lanka

VHW Dissanayake, V Giles… - Journal of Obstetrics …, 2009 - Wiley Online Library
Aim: The aim of these investigations was to study three candidate genes for pre‐eclampsia–
epidermal growth factor (EGF), transforming growth factor alpha, and angiotensinogen–in …