Alpha-synuclein aggregation in Parkinson's disease
E Srinivasan, G Chandrasekhar… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …
Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and …
Huperzine A (HUP) plays a crucial role in Alzheimer's therapy by enhancing cognitive
function through increased cholinergic activity as a reversible acetylcholinesterase (AChE) …
function through increased cholinergic activity as a reversible acetylcholinesterase (AChE) …
A Review On Huntington Protein: Insight Into Protein Aggregation and Therapeutic Interventions
E Srinivasan, V Ram… - Current Drug …, 2022 - ingentaconnect.com
Huntington's disease (HD) is a distressing, innate neurodegenerative disease that descends
from CAG repeat expansion in the huntingtin gene causing behavioral changes, motor …
from CAG repeat expansion in the huntingtin gene causing behavioral changes, motor …
Metagenomics approach to the intestinal microbiome structure and abundance in high-fat-diet-induced hyperlipidemic rat fed with (−)-Epigallocatechin-3-Gallate …
Z Chen, B Liu, Z Gong, H Huang, Y Gong, W Xiao - Molecules, 2022 - mdpi.com
The effects of nanoparticles (NPs) on microbiota homeostasis and their physiological
relevance are still unclear. Herein, we compared the modulation and consequent …
relevance are still unclear. Herein, we compared the modulation and consequent …
Naringenin as a potent anti-amyloidogenic polyphenol against a-synuclein aggregation: a computational approach
MJ Saadh, ZS Ghnim, MS Mahdi, SR Jyothi… - The European Physical …, 2024 - Springer
Misfolding and aggregation of the protein alpha-synuclein (a-syn) triggers Parkinson's
disease PD. Amyloid aggregates, typically rich in β-sheets, are prime targets for reducing …
disease PD. Amyloid aggregates, typically rich in β-sheets, are prime targets for reducing …
Molecular simulation probes the potency of resveratrol in regulating the toxic aggregation of mutant V30M TTR fibrils in Transthyretin mediated amyloidosis
Transthyretin (TTR) mediated amyloidosis is a highly ruinous illness that affects various
organs by aggravating the deposition of misfolded or mutated TTR protein aggregates in …
organs by aggravating the deposition of misfolded or mutated TTR protein aggregates in …
Theoretical investigations of TTR derived aggregation-prone peptides' potential to biochemically attenuate the amyloidogenic propensities of V30 M TTR amyloid …
G Chandrasekhar, R Rajasekaran - Journal of the Indian Chemical Society, 2023 - Elsevier
Transthyretin (TTR) is a cerebrospinal fluid and plasma prevalent protein implicated in
heritable and sporadic amyloidosis. Numerous mutations and a wide range of phenotypes …
heritable and sporadic amyloidosis. Numerous mutations and a wide range of phenotypes …
Structural debilitation of mutation G322D associated with MSH2 and their role in triple negative breast cancer
R Sriroopreddy, P Raghuraman… - Journal of …, 2020 - Taylor & Francis
The missense mutation in the mismatch repair gene MSH2 underlies in several hereditary
cancers. In this study, we have detailed the disruptive mutation of G322D that overtly …
cancers. In this study, we have detailed the disruptive mutation of G322D that overtly …
In silico therapeutic peptide design against pathogenic domain swapped human cystatin C dimer
G Chandrasekhar, R Rajasekaran - International Journal of Peptide …, 2021 - Springer
In humans, cystatin C mediated amyloid aggregation is quite detrimental. It is deemed to
actuate intra-cerebral haemorrhaging, stroke, paralysis and further, turns out to be fatal …
actuate intra-cerebral haemorrhaging, stroke, paralysis and further, turns out to be fatal …